Evaluation of Antimicrobial Activity and Anti-Quorum Sensing of Rosmarinus Methanol Extract on Pseudomonas aeruginosa

Background: The increasing infections caused by resistant P. aeruginosa strains originate from hospitals. Therefore, many efforts are being made to find new herbal compounds as suitable substitutes for antibiotics. Objectives: present study aimed evaluate the antibacterial and anti-quorum activity of Rosmarinus methanol extract on aeruginosa. Methods: This experimental was performed standard clinical methanolic prepared Soxhlet method, antimicrobial evaluated diffusion method in wells microdilution. We examined effect this antibiofilm activity, protease, pyocyanin production order investigate sensing Rosmarinus. Via SPSS 17, we managed conduct statistical analysis. Results: mean diameter growth inhibition zone obtained rosemary at a concentration 500 mg/ml Pseudomonas 18.5 mm, minimum inhibitory 125 mg / ml bacteria. Extract concentrations higher than 62.5 /ml prevented biofilm formation, Conclusions: results can be valuable report their useful role infection control because extracts had activity. It is suggested that more studies conducted identification antimicrobials alternative antibiotics treatment diseases.